Thermo Scientific Orbitrap Ascend™ MultiOmics Tribrid™ Mass Spectrometer

About
The Thermo Scientific Orbitrap Ascend™ MultiOmics Tribrid™ Mass Spectrometer is a state-of-the-art high-resolution accurate-mass (HRAM) LC-MS/MS system built on the revolutionary Tribrid™ architecture — a quadrupole mass filter, dual-pressure linear ion trap, and ultra-high-field Orbitrap mass analyzer operating in tandem. The MultiOmics Edition is specifically configured for maximum coverage and versatility across proteomics, metabolomics, lipidomics, glycoproteomics, and glycomics workflows. It achieves Orbitrap resolution up to 480,000 FWHM at m/z 200, mass accuracy better than <1 ppm RMS with internal calibration, DDA MS/MS acquisition rates up to 45 Hz, and femtogram-level sensitivity. The instrument features Active Ion Management (AIM+) technology, Dual Ion Routing Multipoles (IRMs), a high-capacity transfer tube, and an electrodynamic ion funnel for exceptional ion transmission across a broad mass range. Multiple orthogonal fragmentation techniques — CID, HCD, ETD, EThcD, ETciD, UVPD — are available at any MSn stage. Intelligent acquisition tools including Real-Time Search (RTS), Real-Time Library Search (RTLS), and AcquireX automate experimental decision-making to maximize sample throughput, proteome coverage, and data quality. The Auto-Ready ion source enables fully automated, unattended mass calibration without manual hardware reconfiguration. The instrument is controlled with Thermo Scientific Xcalibur™ software and supports downstream analysis in Proteome Discoverer™, Compound Discoverer™, BioPharma Finder™, and ProSightPC™.