Thermo Scientific TSQ Altis™ Plus Triple Quadrupole Mass Spectrometer

About
The Thermo Scientific TSQ Altis™ Plus is a high-sensitivity triple quadrupole (QqQ) LC-MS/MS system designed to overcome the most demanding targeted quantitation workflow challenges. Built on Active Ion Management Plus (AIM+) technology, it delivers attogram-to-femtogram sensitivity, greater than six orders of linear dynamic range, prototypical selectivity, and superior acquisition speeds across a broad range of molecular types in even the most complex biological, environmental, food, and pharmaceutical matrices. Key hardware innovations include QR5 Plus segmented quadrupole mass filters with hyperbolic surfaces, an optimized high-capacity transfer tube (HCTT), an electrodynamic ion funnel (EDIF) for gentle and efficient ion capture, an Active Reaction Collision Cell II (ARC II) with axial DC fields for ultra-fast SRM acquisition (up to 600 SRMs/second), and an enhanced dual-mode discrete-dynode electron multiplier for extended detector lifetime and six orders of dynamic range. A 5 ms polarity switching time and dwell times as low as 0.3 ms make the TSQ Altis Plus ideally suited for large-scale, multi-compound targeted quantitation with UHPLC separations. The instrument supports high-resolution SRM (H-SRM) at 0.2 Da FWHM for improved selectivity in complex matrices and integrates with Thermo Scientific Chromeleon™ CDS and TraceFinder™ software for complete, regulated LC-MS/MS workflows. Optional interfaces include FAIMS Pro Duo, VeriSpray PaperSpray, and EASY-Spray NG ion sources. The system is compatible with the full portfolio of Thermo Scientific Vanquish UHPLC and Dionex ion chromatography (IC) inlet systems.